Its responsible for carrying oxygen throughout your body. People with IDA have low blood levels of hemoglobin. With IDA, you have anemia (low red blood cell level) thats due to not having enough iron in your body. VenAccess is a trademark of Vifor (International) Inc. Switzerland. You will need frequent medical tests to help your doctor determine how long to treat you with Venofer. %PDF-1.3 Sharing this information can help you avoid potential interactions. Mild side effects of Injectafer can include:*. Medically reviewed by Sanjai Sinha, MD. One study of just under 5000 HRT users found that 43% were affected. (A class of medications describes a group of drugs that work in the same way.). But its important to note that these studies werent designed to show whether Injectafer is safe to use during pregnancy. Selected from data included with permission and copyrighted by First Databank, Inc. Consult your doctor before breast-feeding. Undergoingcancer treatmentwithradiation therapyorchemotherapy drugsmay result inhair loss, which can be devastating to somepeople. However, side effects at the 150 mg dose may indicate that you might not . He is an Affiliate Specialist of the American College of Medical Genetics and Genomics(ACMG), an Associate of the American College of Preventive Medicine(ACPM), and a member of the National Society of Genetic Counselors(NSGC). All rights reserved. Reactions around the injection/infusion site, such as pain, irritation, itching, bleeding, or discoloration after leakage of injection into the skin. 2. Iron sucrose can also be mixed in a. In clinical studies, people who took Injectafer had their hemoglobin level improve as early as 35 days after receiving treatment. Feraheme is also approved to treat IDA in adults who either didnt have improvement in their IDA or had side effects with iron treatment thats taken by mouth. * Feraheme has a boxed warning for this side effect. Do not exceed 1,500 mg of iron per dosing course. Side effects are uncomfortable reactions to medications or drugs. Side effectsare uncomfortable reactions to medications or drugs. And theyll recommend how soon after starting the drug you need to have this level checked. The insurance company will review the prior authorization request and decide if the drug will be covered. The following information describes dosages that are commonly used or recommended. This could happen because Injectafer helps increase their hemoglobin levels, but it doesnt address the underlying cause of their anemia. But its only approved for use in people with CKD who may or may not need dialysis. Allergic reactions are most likely to occur within 30 minutes of receiving Venofer. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Iron-refractory iron deficiency anemia (IRIDA) is a genetic form of anemia. Dizziness. Can poor sleep impact your weight loss goals? For this purpose, Injectafer is approved for use in adults who either: Venofer is also approved to treat IDA. What is the latest research on the form of cancer Jimmy Carter has? Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Some people may also experience skin irritation from the adhesive tape and other medical equipment used during the procedure. And this over-activation is what may lead to an allergic reaction or a delayed allergic reaction. Can diet help improve depression symptoms? Possibleside effectsareweight gainand suicidal thoughts. If your symptoms or health problems do not get better or if they become worse, call your doctor. Last reviewed . Some people are simply allergic to an active ingredient in the medication, so the body responds undesirably. Notify your healthcare provider if you are pregnant, or planning to get pregnant or breastfeeding. For some people, after receiving one treatment course (two doses) of Injectafer, their IDA is resolved. This medicine may cause serious types . The Food and Drug Administration (FDA) approves prescription drugs such as Injectafer to treat certain conditions. Patients should induce vomiting or evacuate the stomach by lavage during Venofer overdoasge. This may lead to the person needing a higher dose compared to someone who is muchsmaller. This website is intended for use by US healthcare professionals only. Have blood work checked as you have been told by the doctor. Last updated on Feb 20, 2023. If you have iron deficiency anemia (IDA), consuming moderate amounts of alcohol may be safe, if your doctor tells you its OK. (With IDA, you have a low level of red blood cells thats caused by not having enough iron.). Some products that may interact with this drug include: vitamin products, other iron-containing products. You should not receive Venofer if you have ever had an allergic reaction to an iron injection, or if you have iron overload (the buildup of excess iron) or hemochromatosis. You may wonder how Injectafer compares with other medications that are prescribed for similar uses. If you need to store Venofer at home, talk with your doctor, nurse, or pharmacist about how to store it. Do not flush down a toilet or pour down a drain unless you are told to do so. But they wont receive a total cumulative dose of more than 1,500 mg of Injectafer. Before you receive Venofer, tell your doctor if you have low blood pressure, hepatitis, or if you have received many blood transfusions in the past. People who weigh 110 pounds (about 50 kilograms) or more will receive two separate Injectafer doses of 750 milligrams each. Generics tend to cost less than brand-name drugs. Dilute Venofer in a maximum of 250 mL of 0.9% NaCl. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. signs of inflammation in the lining of your stomach - pain or swelling, bloating, nausea, vomiting, loss of appetite, diarrhea, fever. You may report side effects to FDA at 1-800-FDA-1088. Phosphorus is an electrolyte that your body needs in order to make energy. Do not start, stop, or change the dose of any drug without checking with your doctor. If you miss an appointment for your Injectafer dose, youll need to call your doctors office. Your doctor may also recommend that you take iron supplements by mouth (if you havent tried these supplements in the past). Follow all instructions closely. To make sure Venofer injection is safe for you, tell your doctor if you have: hemochromatosis or iron overload (the buildup of excess iron). Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. TheNational Instituteof Health (NIH) and the U.S.Food and Drug Administration(FDA) monitor the side effectsof new and approved medications to ensure safety. Maximum concentrations of Injectafer are achieved within 15 minutes to 1.21 hours following administration. It's a more immediate treatment than supplements or dietary changes. There may be risks to the mother and fetus associated with untreated IDA in pregnancy. reactions at the site of the injection. If you have questions about the safety of breastfeeding while youre taking Injectafer, talk with your doctor. If youre interested in finding an alternative to Injectafer, talk with your doctor. *Patients are calculated based on an estimated annual cumulative dose. Injectafer and Venofer have different approved uses, but theyre both used to treat IDA in people with CKD. I had Venofer infusions, 2 rounds now in the span of three years. I got Venofer twice in the last few years and now my iron deficiency is worse than ever, first time my hemoglobin is down to 11,2. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. And this could lead to weight gain, if they increase their food intake. Many people believe they are suffering fromside effectsand may actually be suffering from anothermedical condition, such as havingdifficulty breathingorshortness of breath, which could be a heartattack. The recommended dosing guidelines of Injectafer for treating IDA are based on patient weight, as follows: Injectafer contains ferric carboxymaltose, which is a polymer that releases iron into the body. Orofer S 50 Injection 1 Injection in 1 Packet 147. <> But for most people whove developed hypophosphatemia with Injectafer, the condition resolved within 3 months. Most mild side effects of Injectafer typically go away within about 30 minutes of receiving your dose of the drug. Keep all drugs out of the reach of children and pets. Potential side effects that are usually mild may include, but are not limited to: Headache Nausea Dry Mouth Stomachache Dizziness Diarrhea Constipation These side effects may not impact life too much and may only be temporary. FG Trade/E+ sia Getty Images Boxed warnings alert doctors and patients about drug effects that may be dangerous. Injectafer is approved to treat iron deficiency anemia (IDA) in certain adults with the condition. But for other people, their IDA returns after treatment with Injectafer. Orofer S 100 Injection 1 Injection in 1 Packet 286 301 5% off. If you notice other effects not listed above, contact your doctor or pharmacist. muscle pain. 1 0 obj TheNational Instituteof Health (NIH) and the U.S. Food andDrug Administration(FDA) monitor theside effectsof new and approved medications to ensure safety. These drugs have been compared in a clinical trial of adults with both IDA and CKD who didnt need dialysis. However, Injectafer has been studied for use in children with iron deficiency anemia (IDA). You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Call your doctor right away if you have chest pain, cough or the need to cough, dizziness, passing out, shortness of breath, sweating, or throat tightness. We cancelled my 5th because of the reaction. This allows them to manage any side effects that you may have following your dose. While the side effects that occur during treatment with these drugs are increasingly well-cataloged, the long-term side effects that may result from receiving these drugs are only beginning to be studied. Iron is important for many functions in the body, especially for the transport of oxygen in the blood. In stock alternatives of Venofer (based on Iron Sucrose ) Orofer S 200 Injection 1 Injection in 1 Packet 540 569 5% off. This medication is given by injection into a vein as directed by your doctor. With IV infusion, the drug is given as a slow drip into your vein over a period of time. Allergic reaction As with most drugs, some people can have an allergic reaction after taking Injectafer. To learn about other mild side effects, talk with your doctor or pharmacist, or see Injectafers package insert. How long does iron infusion stay in your system? wAd**CgI%"nn{Oa[q{r5 These effects typically last between 7 and 11 hours. Its important to note that youll get Injectafer doses from a doctor or healthcare professional in a medical facility. Also, keep in mind that if your anemia is causing certain symptoms, treatment with Injectafer may help those symptoms go away. No, you dont need to follow a specific diet plan while youre using Injectafer unless your doctor recommends otherwise. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. Effectiveness of Injectafer compared with iron thats taken by mouth. Here we look at how Injectafer and Venofer are alike and different. Venofer treatment may be repeated if iron deficiency reoccurs. Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. If youre not sure if youll need to get prior authorization for Injectafer, contact your insurance company. Venofer is indicated to treat iron deficiency anemia (IDA) in adult and pediatric patients (2 years and older) with chronic kidney disease (CKD). So theres no recommended pediatric dosage for Injectafer. If you have a severe allergic reaction to Injectafer after youve left the medical facility where you received your dose of the drug, call your doctor right away. The following information is provided for clinicians and other healthcare professionals. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Side effectswill last a very long time if the cause of them is not resolved. Iron is a vital mineral in the body, central to transporting oxygen around the body in the hemoglobin. Injectafer contains the active drug ferric carboxymaltose. chest pain. Call your doctor for medical advice about side effects. You will need to talk about the benefits and risks to you and the baby. I can't take oral supplements because they cause horrible debilitating Constipation. For some people, it may be OK to continue taking a multivitamin that contains iron. Only 10 mg may be excreted by the body the next time it goes through the liver, and possibly only 5 mg the nextpass. In the second group, some people switched from taking iron by mouth to taking Injectafer. Together, you and your doctor can develop a treatment plan thats best for you. So the goal of anemia treatment is to increase your hemoglobin level back to a value thats within a normal range. Muscle cramps, nausea, vomiting, strange taste in the mouth, diarrhea, constipation, headache, cough, back pain, joint pain, dizziness, or swelling of the arms/legs may occur. However, some people may have weight changes as they have improvement in their anemia, which Injectafer is used to treat. Do not exceed 1,500 mg of iron per dosing course. But for other people, their anemia may come back after Injectafer treatment. For instance, there are some experts who believe there are long-lastingside effectsfromCOVIDthat were not aware of just yet. Injectafer contains the active drug ferric carboxymaltose, while Venofer contains the active drug iron sucrose. Headache. For people weighing 50 kg (about 110 lb) or more, administer Injectafer in two doses of 750 mg, at least 7 days apart. In clinical studies, diarrhea was reported in less than 1% of people taking Injectafer. Both Injectafer and Venofer belong to a class of medications called iron replacement products. Injectafer is approved for use in adults who either: Injectafer contains the active drug ingredient ferric carboxymaltose. A boxed warning is the most serious warning the Food and Drug Administration (FDA) can issue about a drug. Learn how to store and discard medical supplies safely. If you have any questions about Venofer, please talk with your doctor, nurse, pharmacist, or other health care provider. Things to remember when you fill your prescription. fever, cold or flu symptoms (sore throat, cough, stuffy nose, sneezing); bruising or irritation where the medicine was injected. Knowing how longside effectslast can help with the decision on whether to use a particulardrug. It can be given as a slow injection over 2 to 5 minutes or as an infusion. Tell your doctor if you are pregnant or plan to become pregnant. reese0809 1 yr. ago. Hemoglobin is a protein thats found in your RBCs. The way thatprescription drugsand evenover-the-countermedications interact with a body is influenced by manyfactors. Injectafer can be exposed to temperatures between 59F to 86F (15C to 30F) for a short period of time. Now I've just got mild nausea and have felt faint/dizzy a few times which is rare for me. You will be watched closely for at least 30 minutes to make sure you do not have an allergic reaction. <> Injectafer and Venofer can cause very similar side effects, but some different ones as well. Before taking Injectafer, be sure to tell your doctor or pharmacist about any medications you take, including any over-the-counter vitamins or supplements. If a person does not have an allergic response or any other unanticipated reactions, a doctor will administer the remaining iron. The benefit of treating your condition during pregnancy may outweigh any risks. No, Injectafer itself wont make you gain weight. Injectafer can cause low blood levels of phosphorus, which is a condition called hypophosphatemia. Source: Wolters Kluwer Health. Weight changes may be due to symptoms of anemia improving. ByDr. Available for Android and iOS devices. Laboratory tests (such as complete blood count, ferritin, transferrin, total iron binding capacity-TIBC) should be performed periodically to monitor your progress or check for side effects. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Someside effectsare temporary or last as long as the person continues takingprescription medicine. Click below for effective ways to alleviate the discomfort felt fromside effects and learn how to get a free Medication and Drug Reaction DNAReport. The dosing for iron replacement treatment in pediatric patients less than 2 years old with Peritoneal or Hemodialysis-Dependent CKD or Non-Dialysis-Dependent CKD have not been established. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. In this study, compared with their level before treatment: Injectafer isnt currently approved for use in children. After 5 weeks of treatment: This study didnt determine if either drug was better than the other. (And Injectafer is used to treat IDA.) Theseeffects of medicine on thebodycan also lead to medication non-compliance and worsening of themedical conditionthey are meant to treat. How is Venofer (iron sucrose) given? Injectafer may not be right for you if you have certain medical conditions or other factors affecting your health. . (One treatment course includes two doses of the drug.) Procedure Details Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Taking a larger dose of LSD can extend the duration of the trip, but generally, the main effects of LSD don't tend to last any longer than 12 hours. The following lists contain some of the key side effects that may occur while taking Injectafer. You are encouraged to report side effects to American Regent, Inc. at 1-800-734-9236 or to the FDA by visiting www.fda.gov/medwatch or calling 1-800-FDA-1088. If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Do not share your drugs with others and do not take anyone else's drugs. But so far I feel better than before the infusion. XAO$$d|0tX1`Q$Il#FBm}{#h!/;[bOvvg7 ?tMl7/+wya^,~PA}6&Ftb19OeJ6-a3acKjcpkeGq+7/nO AJJ:Okyfp;xw|]McmK?9"t0m%. 5 0 obj They have been a god send. This information is not specific medical advice and does not replace information you receive from the healthcare provider. Injectafer is a brand-name prescription drug. Keep in mind that the risk of certain pregnancy-related problems can be increased if iron deficiency anemia (IDA) is left untreated. And if you dont have an allergic reaction to your first dose of a drug, its typically safe to assume you wont have an allergic reaction to doses that follow. In pediatric patients the most common side effects (>2%) are headache, viral respiratory tract infection, peritonitis, upset stomach, throwing up, fever, dizziness, cough, arteriovenous fistula thrombosis, hypotension and hypertension (increased blood pressure). The time it takes to infuse Venofer (iron sucrose) depends on your age, if you're on dialysis, and the type of dialysis you need. Others last much longer (even a lifetime), which can be quite traumatizing to people. Call your doctor for instructions if you miss an appointment for your Venofer injection. (A generic drug is an exact copy of the active drug in a brand-name medication.) If the underlying cause of your anemia isnt addressed, theres a chance your anemia could come back after Injectafer treatment. There are currently no generic forms of either drug. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Venofer. You should not receive Venofer if you have known allergies to iron sucrose. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. This means you would get two Injectafer doses of 720 mg each. As with all medications, the cost of Injectafer can vary. Drug interactions: DayQuil can interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements. Follow your doctor's directions carefully. Its given by either intravenous (IV) infusion or slow IV injection. Injectafer and Feraheme can cause very similar side effects, but some different ones as well. Theyll do this by checking certain blood tests. After getting each dose of Injectafer, your healthcare professional will monitor you for at least 30 minutes. Typical Injectafer doses for iron deficiency anemia (IDA) depends on your body weight. However, since peoples bodies react so differently to drugs, they often have to change their stance on certain drugs. You would receive 15 mg of Injectafer per kilogram of body weight for each of your two doses. If this happens, you may need to get another treatment course of Injectafer, if your doctor recommends it for you. One class of immune checkpoint inhibitors targets the protein PD-1, which acts as a brake to keep the immune system in check. Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Do not double the dose to catch up. People in the study received treatment with either Injectafer or Venofer. This is not a complete list of side effects and others may occur. I actually was constipated after my 3rd but didn't think anything of it. The researchers looked to see how well each drug worked to increase peoples hemoglobin level. This is because alcohol reduces your bodys absorption of certain nutrients that are necessary to make red blood cells. No, you most likely wont take Injectafer long term. What is Venofer? Call your doctor for medical advice about side effects. This gives a total cumulative dose of 1,500 mg of Injectafer. Injectafer contains the active drug ferric carboxymaltose. Venofer is used to treat iron deficiency anemia in people with kidney disease. Its not currently available in generic form. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. To help make sure that you dont miss an appointment for your Injectafer dose, try setting an appointment reminder on your phone. To help make sure that you dont miss appointments for your Injectafer doses, try setting an appointment reminder on your phone. However, not treating iron deficiency anemia during pregnancy may cause complications such as premature birth or low birth weight. Learn how to store and discard medical supplies safely. Theseside effectsmay last as long as they are undercancer treatment. As described just above in the Allergic reaction section, some people may have an allergic reaction after getting a dose of Injectafer. What Is the Cost of Whole Genome Sequencing (WGS)? If you do breastfeed while youre taking Injectafer, the drugs manufacturer recommends that you monitor your child for side effects of the drug. What to know about iron deficiency anemia, took oral iron treatment and didnt have improvement in their IDA or had side effects that couldnt be managed, or, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your tongue, mouth, or throat, have a medical condition that affects their bodys ability to absorb phosphorus, take medications that affect how well their, ferrous sulfate (Fer-Iron, Slow-FE, Feosol), people who took Injectafer had their hemoglobin level increase by an average of 1.1 grams per deciliter (g/dL), people who took Venofer had their hemoglobin increase by an average of 0.9 g/dL. All patients receiving Venofer require periodic blood tests to monitor the amount of iron in the blood. These side effects can range from being mild to severe. Iron sucrose can harm an unborn baby if you have a severe reaction to this medicine during your second or third trimester. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. For people weighing less than 50 kg, administer Injectafer in two doses of 15 mg/kg of body weight, at least 7 days apart. These people may lose weight as their anemia improves because theyre more active. Its not known if Injectafer is safe to use during pregnancy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Details. You may report side effects to Health Canada at 1-866-234-2345. What to Expect When You Get Your Whole Genome Sequenced, DNA Data Can Help You Understand Ehlers-Danlos Syndrome (EDS). With IV infusion, the drug is given as a slow drip into your vein over a period of time. Their medical staff can help you set up another time to receive your Injectafer dose. Terminal half-life ranges from 7 to 12 hours. These changes could help improve your anemia on a long-term basis. 3 0 obj Iron sucrose injection has a molecular weight of approximately 34,000 - 60,000 daltons and a proposed structural formula: intense abdominal pain. Brand-name medications usually cost more than generics. Common side effects may include: fever, cold or flu symptoms ( sore throat, cough, stuffy nose, sneezing); high or low blood pressure; headache, dizziness; nausea, vomiting; diarrhea; Its not known how often people taking a treatment other than Injectafer had diarrhea. Its responsible for carrying oxygen throughout your body. Its not known for sure how often this condition occurred during clinical trials, or if it occurred at all during the trials. Reblozyl is a brand-name prescription medication used to treat anemia in certain blood disorders. This is why the FDA hasa programcalledMedWatchthat encourages Americans to report adversereactions. If youre taking iron pills, be sure to tell your doctor before starting Injectafer. And babies born to those who took Injectafer during pregnancy didnt have any major congenital anomalies (also sometimes called birth defects). stream Feraheme also comes as a liquid thats given by IV infusion. IQVIA [NSP Audit from MAT November 2013 to November 2018]. The study also didnt show if one treatment was worse than the other. However, many people have no side effects or only have minor side effects. Venofer pregnancy and breastfeeding warnings. weakness. Both of theseside effectscould worsen depression and lead tolife-threateningconsequences. If you think there has been an overdose, call your poison control center or get medical care right away. Most of these side effects may go away within a few days or a couple of weeks. You can also write a reminder on your calendar. And this would give you a total cumulative Injectafer dose of 1,440 mg. Injectafer should be given in two doses. Before using, check this product visually for particles or discoloration. There may be drug take-back programs in your area. Daiichi Sankyo, Inc., the manufacturer of Injectafer, offers a program called injectconnect, which may help lower the cost of the drug. Talk to your pharmacist for more details. (A generic drug is an exact copy of the active drug in a brand-name medication.). If you have questions about using Injectafer in a child, talk with your doctor. Iron infusion benefits. A variety of tests can diagnose iron deficiency anemia. Injectafer comes as a liquid solution inside vials. Weight influences how fast medication breaks down in the body, so it also affects how longside effectswill last. Treatment with Venofer injections can make it harder for your body to absorb iron medications you take by mouth.