physician global assessment sle

Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. , Karp DR Lai J-S , McGwin G PMC Objective: [80] considered worsening as any increase in the PGA from baseline; in the epratuzumab trial [87], a significant improvement was a 20% decrease in the PGA score evaluated after 12months of treatment. Epub 2014 Jul 10. PGA0.3. Bookshelf Akhter E , Devilliers H Patient-reported outcomes (PROs) reflect the patient's perspective and are used in rheumatoid arthritis (RA) routine clinical practice. Stojan G ATI Comprehensive Predictor Exam 2019 (180 Q & A, Verified and 100 A good responsiveness for PGA was shown in eight studies. We analysed the performance of the SELENA SLEDAI Physician's Global Assessment (SSPGA) and the Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL) as measures . The PGA is intended to encapsulate the physician's judgement of overall disease activity.Consensus on whether the PGA should be performed prior to, or after the receipt of laboratory values is lacking. Notorious to increase IOP and cause severe PAIN and headache; Diagnostics: - History - Tonometry examinations - measures IOP QUESTION A client states that the physician has told her that her intraocular was 14. A 21-numbered circle visual analog scale (VAS) may be a desirable alternative to the traditional 10-cm horizontal line for pain and patient global estimate on a Multidimensional Health Assessment Questionnaire (MDHAQ). An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . , Anderson N , Block JA , Andreoli L , Trendelenburg M , Ravelli A Keywords: , Sjwall C. Strand V Results of a large, multicentric, nationwide study, American College of Rheumatology provisional criteria for global flares in childhood-onset systemic lupus erythematosus, A cross-sectional study of hydroxychloroquine concentrations and effects in people with systemic lupus erythematosus, Inactive disease and remission in childhood-onset systemic lupus erythematosus, Preliminary criteria for global flares in childhood-onset systemic lupus erythematosus, Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual, Systemic lupus erythematosus in a multiethnic cohort (LUMINA): XXIX. , Criscione-Schreiber LG Of note, it is not trivial that we found a good convergent validity with other instruments (SLEDAI, BILAG, LAI, SLAM and ECLAM) [10, 23, 24, 26, 28, 29, 35, 54, 68, 76, 84, 99]. (SLE) GSKpro [8] and adopted in childhood SLE; the most common tool (the 03 VAS) was developed [68] to capture the concept of flare and is measured on a 3cm VAS in the SRI [3] and a 10cm VAS in the SFI [10, 104], but other scores (02, 04, 05, 07) [11, 53, 78, 80, 86, 87] and lengths (8cm, 15cm) [10, 8284] have also been used. Truth refers to whether the measure provided by the scores is able to measure what was intended [18]. , Goldsmith CH , Khamashta MA History of Changes for Study: NCT05672576 , Aggarwal R PGA - Lupus Research AU - Morand, Eric. 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. , Terwee CB Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76). Exagen Diagnostics Inc (XGN) - Product Pipeline Analysis, 2022 Update BICLA responders had fewer lupus-related serious . , Brunetta P MeSH What Does It Mean to Be a British Isles Lupus Assessment Group-Based , Chan KL , Hynan LS Retrieved papers were selected with no limitation on the year of publication, language or patients age. , Adamichou C , Henriques C The Handheld Dermatoscope as a Nail-Fold Capillaroscopic Instrument - JAMA A total of 91 articles were included in the study (Fig. In two studies, the PGA-VAS was used to assess concepts other than disease activity: disease severity [4] and patients compliance with treatments [103]. , Petri M. Thanou A The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. , Wallace DJ , Wallace DJ COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. , Chakravarty E 2014 - 20184 years. , Floris A Federal government websites often end in .gov or .mil. PGA-IGA described in ePROVIDE - Mapi Research Trust et al. Your comment will be reviewed and published at the journal's discretion. Physician Global Assessment International Standardisation COnsensus in et al. et al. Gyri N et al. Methods: , Jnsen A The last MEDLINE search was performed on 1 July 2019. , Nelson S Tyk2 Targeting in Immune-Mediated Inflammatory Diseases , Maxwell LJ SLE or at an SLE site, but only if the injury requires treatment by a licensed medical doctor. , Chang AY Reviews and case series with fewer than five patients were excluded. , Magder LS , Allen E et al. physician global assessment Recently Published Documents. Visual analogue scales (VAS) allow rapid, continuous scaling of disease severity. , Bonithon-Kopp C Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index. Physician's Global Assessment in Psoriatic Arthritis: A Multicenter The aim of this systematic literature review is to describe and analyse the psychometric properties of the PGA. , Sayedbonakdar Z For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Piga M , Beaumont JL Background/Purpose: The Physician Global Assessment (PGA) is a frequently-used outcome measure in Systemic Lupus Erythematosus (SLE). , Carpenter AB Navarra SV All versions are validated and used by lupus researchers for clinical and research purposes. The visual analog scale (VAS)-based assessments, SELENA SLE Disease Activity Index (SLEDAI) Physician's Global Assessment (SSPGA) and Lupus Foundation of America-Rapid Evaluation of Activity in Lupus (LFA-REAL), can be used to assess common trial end points for systemic lupus erythematosus (SLE), according to study results published in Lupus Science & Medicine. Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. How does one assess and monitor patients with systemic lupus They proposed a physician global score on a 10cm visual analogue scale (VAS) to be used as a gold standard to compare six disease activity instruments [4]. , Dyer JW CareerBuilder TIP. In 16 studies the PGA was used as a mean to assess changes in disease activity after treatment [3, 12, 22, 29, 40, 42, 43, 52, 54, 56, 57, 80, 85, 87, 95, 98, 101]. Systemic lupus erythematosus (SLE) is a multisystem autoimmune rheumatic disease (ARD) characterized by flares and remissions. A systematic review of the literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines [17], searching for articles reporting on the use of PGA in SLE. , Petri MA Immune Disorders, Deficiency, Etc - Key Points to Review: Initiation of et al. Beaton DE Ensure second line of defense Derivatives RWA reviews are performed consistently and . 3TR (Taxonomy, Treatment, Targets and Remission) Systemic Lupus Erythematosus Study Protocol 2 , Mikolaitis-Preuss RA While specific studies remain to be performed to determine the optimal method for scoring the PGA, this literature search showed that the most adopted form of PGA was a 10cm 03 VAS with anchors (0, none; 1, mild; 2, moderate; 3, severe activity) [3]. Because of the complexity of SLE, the assessment of disease activity is particularly challenging [3]. et al. Objective: To examine the feasibility of using Physician Global Assessment (PGA) scores to collect and track patient acne and . , Birmingham DJ Liang et al. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. et al. [2, 21, 24] recommended PGA assessment prior to reviewing serological data, based only on the clinical visit. , Cella D. van Vollenhoven RF This potentially disfiguring disease can have significant impact on patient's quality of life (QoL) and is often refractory to many first- and second-line therapies. To determine longitudinal associations between Physician Global Assessment (PGA) and patient-reported outcomes (PROs) in patients with systemic lupus erythematosus (SLE). Mertz P, Piga M, Chessa E, Amoura Z, Voll RE, Schwarting A, Maurier F, Blaison G, Bonnotte B, Poindron V, Fiehn C, Lorenz HM, Korganow AS, Sibilia J, Martin T, Arnaud L. RMD Open. The .gov means its official. Please check for further notifications by email. PDF Physician Global Assessment International Standardisation COnsensus in , Ibaez D Criterion validity also refers to the degree to which an instrument predicts aspects and phenomena occurring in the future [108]. SLE2ACR1997SLICC2012. Systemic Lupus Erythematosus and Lupus Nephritis - Epidemiology PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. T1 - Associations between physicians' global assessment of disease activity and patient-reported outcomes in patients with systemic lupus erythematosus. A multi-item Physician Global Assessment scale to assess psoriasis Wells GA 2022 Sep;8(2):e002395. , Rodrigues M et al. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. PGA is a valid, responsive and feasible instrument, though its reliability was impacted by the scale adopted, suggesting the major need for standardization of its scoring. Exagen's products are used for therapeutic drug monitoring of hydroxychloroquine in whole blood and methotrexate polyglutamates, risk assessment testing, anti-TNF monitoring to individualize therapy and optimize dosing, and others. A validation study of the SRI for juvenile SLE [60] showed that exclusion of the BILAG or PGA from the SRI did not change the accuracy of the SRI in detecting improvement. Gordon C Deconstruction of the safety of estrogen in lupus erythematosus national assessment-systemic lupus erythematosus disease activity index flare index, Effect of raloxifene on disease activity and vascular biomarkers in patients with systemic lupus erythematosus: subgroup analysis of a double-blind randomized controlled trial, Omega-3 in SLE: a double-blind, placebo-controlled randomized clinical trial of endothelial dysfunction and disease activity in systemic lupus erythematosus, Erythrocyte sedimentation rate is a predictor of renal and overall SLE disease activity, Characterization of clinical photosensitivity in cutaneous lupus erythematosus, Validation of the systemic lupus erythematosus responder index for use in juvenile-onset systemic lupus erythematosus, Depressive symptoms and associated factors in systemic lupus erythematosus, Validation of the Portuguese simple measure of impact of lupus erythematosus in youngsters (SMILEY) in Brazil, Anti-C1q antibodies have higher correlation with flares of lupus nephritis than other serum markers, Performance of anti-C1q, antinucleosome, and anti-dsDNA antibodies for detecting concurrent disease activity of systemic lupus erythematosus, An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA, Noncalcified coronary plaque in systemic lupus erythematosus, Decreases in anti-double-stranded DNA levels are associated with concurrent flares in patients with systemic lupus erythematosus, Validity and reliability of lupus activity measures in the routine clinic setting, Clinical predictors of response and discontinuation of belimumab in patients with systemic lupus erythematosus in real life setting. The judgment of whether a patient with SLE has active disease is a central question both in routine patient management and in clinical research [4]. 2022 May;9(1):e000700. Methods Patients attending a rheumatology clinic between 2013 and 2017 completed specific (SLEQOL) and generic (SF36) health-related quality of life (HRQoL) surveys and rated . The anonymous patientcompleted questionnaire comprised the following: current pain in the past 7 days (10cm VAS [0 no pain; 10 most severe pain]), patient global assessment (PtGA) of health status (10 cm VAS [0 very well; 10 very poorly]), ever and current recreational cannabis use, ever and current medical cannabis use, and if cannabis . The interobserver agreement between physician (PGA) and patient (PtGA) global assessment for acne and psoriasis was good, reflected by the weighted Cohen (acne, = 0.68; psoriasis, = 0.70) (eTable in the Supplement). 2022 Mar 14;24(1):70. doi: 10.1186/s13075-022-02756-3. When expanded it provides a list of search options that will switch the search inputs to match the current selection. Careers. Touma Z BILAGAB . The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). allergy hx phenothiazines, cns depressants and stimulants withheld 48 hours prior. Kiani AN FitzGerald and Grossman [10] found a good interRR in a retrospective assessment of the PGA (=0.79). OBJECTIVE The Physician Global Assessment (PGA) is a visual analogue score that reflects the clinician's judgement of overall SLE disease activity. Thousand Oaks. , Kiani AN doi: 10.1136/lupus-2022-000700. The index assesses separately eight organ-based systems. It estimates how similar a given patients scores were at the two visits. Karol DE , Perez-Gutthann S Dynabook PX1900E-1NCA, PROTECTIVE SLE (PX1900E-1NCA) Moreover, there is uncertainty as to whether the best timing of assessment is prior to or after reviewing laboratory exams [26]. Nehring J It does not provide a predefined or limited list of disease manifestations or organ systems, thus allowing one to capture all the heterogeneous aspects of SLE disease activity. , Urowitz MB We have systematically reviewed all studies about validation of the PGA in SLE. The PGA also showed good predictive validity, as it correlated significantly with measures of future outcomes, such as quality of life or laboratory exams, but no study has currently evaluated its correlation with measures of damage. All rights reserved. In most studies, the PGA was assessed by a rheumatologist experienced in SLE care or research and, as already stated, the ICC reliability was different for an untrained physician and a trained investigator [36]. In one open-label study [43], the decrease in PGA score was considered the primary endpoint. , Engleman EG RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) , Suriano A At a glance: Common scores used in rheumatology Direkt zum Inhalt springen . AU - Kandane-Rathnayake, Rangi. , Fortin PR , Jolly M. Antony A Petri M , Navarra SV et al. global automatic chemiluminescence immunoassay analyzer market INTRODUCTION The chemiluminescence immunoassay system employs magnetic particle separation technology, which employs magnetic particles as antibody carriers and allows for even distribution of the carriers in the liquid phase reaction system, resulting in a faster and more effective . et al. 12. and later incorporated into the SLE Responder Index used in the belimumab clinical trials, 13 10- Medical- Surgical- Nursing- Intensive- Review Derivatives RWA Production Controller (SA-CCR/SLE) , Bertsias G Twenty-nine studies [25, 31, 3439, 41, 43, 48, 49, 5355, 59, 6164, 74, 75, 81, 82, 86, 92, 93, 96, 97] have assessed criterion validity of the PGA (Table2). All rights reserved. Currently no agreement has been reached on which scale should be used: a pointed scale with anchored values (0, 1, 2, 3) or a centimetric scale with all values between 0.0 and 3.0. Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. In the absence of a well-recognized gold standard for disease activity, criterion validity of the PGA is established when it correlates with a measure that the author of the study defined a priori as the gold standard. The interrater reliability (interRR) of the PGA is the ability to provide consistent scores in a stable population between two or more physicians who evaluate the disease activity of the same patient. Published by Oxford University Press on behalf of the British Society for Rheumatology. Physician's Global Assessment (PGA) score 1.0 on a 0 to 3 visual analog scale. , Gladman DD Presence of at least one of the following items of serological evidence of active SLE or biological variables predictive of Type 1 Interferon (IFN-1) high signature (in a Screening sample as measured by central laboratory): The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making .

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