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Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Hydroxyzine is usually given orally twice to three times daily in dogs, cats, horses and birds. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. J Biol Chem 2007;282(28):20059-20063. Dosage Chart Most commonly, immunotherapy involves injecting gradually increasing doses of a specific allergen subcutaneously (just under the skin), explains White. The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. 13. Allergies can develop at any time, in any horse, and for virtually any reason. Is it horrendously expensive? @stb its definitely not cheap. Allergies are generally managed based on the severity of clinical signs. Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. Qualifies for Zoetis Petcare Rewards! Herbs to Help Horses Breathe More Easily - HolisticHorse.com My Docs are among the first in the country to use this drug on itchy and wheezy horses. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. You may give this medicine with or without food. Oral . Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction.11 Little et al compared oclacitinib to cyclosporine. Therefore, the recommended initial dosage for dogs 6.6-9.9 lbs is of a 3.6 mg tablet twice daily. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. No texts please., Horse breeding from planning through foal care, Horse-health-problem risk factors, prevention, diagnosis, and treatment, Design and maintain a healthy horse operation, Prevention and treatment for problems of the equine foot, How to care for the basic health needs of horses, Prevention, diagnosis, and treatment of leg lameness, Proper feeding practices for foals, adult horses, and older horses, All aspects of caring for performance horses, News and issues for equine health professionals, Discussions about the welfare of our equine friends. If the patient remains stable and other controlling measures-such as allergen avoidance, allergen immunotherapy, and preventive topical therapyhave been implemented, the use of oclacitinib can be limited to flare control. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as, While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease. Works on all common sources of allergens. 24. Loft K, Simon B. Skin allergies can also cause pruritus (itching) and associated hair loss. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. 28. Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. Speak to yourveterinarian in an emergency. Rosenkrantz WS, Bourgeois AS. Dawn M. Cleaver, DVM - Food and Drug Administration J Zoo Wildl Med 2017;48(3):818-828. The most common side effect is lethargy, dry mouth, and urinary retention. Speak to yourveterinarian in an emergency. That was 5-6 years ago now. Apoquel: The Fast Acting And Safe Itch Relief For Dogs - CanadaPetCare Blog This site is for US animal healthcare professionals. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. Uses for Apoquel The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. 15. 10. Equine Drug Dosage Calculations | Equimed - Horse Health Matters 22. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs.17 A follow-up study was conducted with a higher dose (0.7 to 1.2 mg/kg) and a longer induction period (28 days). In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. Apoquel - Lodi Veterinary Care How Should It Be Given? Transdermal applicator designed for easy handling and accurate dosing. Option 2 is the Aservo Equihaler. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. Apoquel delivers onset of relief within 4 hours and effectively controls itching within 24 hours. Frank RK, Galvan BA, Schoell AR, et al. I had my dog on it and the price was pretty steep. Renal Anemia, or . Both can be very serious. Apoquel tablets provide quick relief for itching and inflammation. 19. We have been using an inflatable fleece e-collar on her . How Organized Are Your Horses Health Records? Recently, researchers have delved into the causes and consequences of what now falls under the umbrella term equine asthma. Option 4 is an oral tablet called Apoquel. and unfortunately grass and dust are the main culprits. Stay up-to-date on the latest news about your horse's health with FREE newsletters from TheHorse.com. Apoquel for dogs: Vet's guide to dosage, uses and side effects By blocking cytokines, Apoquel blocks your dog's skin from itching and inflammation. This treatment is typically effective, but the steroid is still absorbed into the body, which can result in laminitis risk, similar to Option 1. U.S. Food and Drug Administration Center for Veterinary Medicine 7500 Standish Place Rockville, MD 20855 www.fda.gov . See full Excede for Swine Prescribing Information. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days.7,8 Treatment success was based on reductions from baseline of at least 2 cm on the owner-assessed visual analog scale and at least 50% on the clinicians Canine Atopic Dermatitis Extent and Severity Index (CADESI-02). This makes it a common site for the bodys expression of allergic reactions. We can let your veterinarian know that you are interested in our compounded Dexamethasone. It is most risky in horses that have metabolic disease like Equine Metabolic Syndrome (insulin resistance), PPID (cushings), or those that are overweight. Apoquel | 1800PetMeds Dexamethasone commonly is used in horses to treat allergic reactions such as respiratory allergies, chronic obstructive pulmonary disease (heaves), hives, itching and inflammatory diseases including arthritis. Six adult horses with a mean weight of 528 kg were administered a single dose of 0.5 mg/kg oclacitinib maleate. However, these studies have shown that oclacitinib can be a good alternative therapy to treat feline pruritus, especially for patients that do not respond to other treatments or do not tolerate steroids. Topical suspension administered in the ear. White believes that while further research in horses is warranted, veterinarians should consider latex exposure a potential risk to equine respiratory health. Cost is about $10 per day for the first few weeks of treatment, and may decrease to around $5 per day depending on the horses response. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. Every cough means something is a common saying among equine veterinarians. Pulsoni D, Freire A, Ferreira DR. Juvenile-onset ischemic dermatopathy in two dogs treated with oclacitinib. 1. For maintenance therapy, the same dose (0.4 to 0.6 mg oclacitinib/kg bodyweight) should then be administered only once a day. Since some horses have both "types" of asthma, you may need to try a stall without bedding, or experiment with different types of bedding. Apoquel side effects- a veterinary dermatologist's - Pet Derm Clinic Apoquel for horses - Horse Care - Chronicle Forums She is a New-York-based freelance author with a passion for equine health and veterinary care. Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? If she suspects a product or ingredient to be the source of an allergic reaction, Fultz recommends performing elimination trials. Left untreated, these conditions can not only cause discomfort but also lead to raw, broken skin that allows bacteria to invade and infect. It definitely makes them more comfortable. 6. Im hoping those are things I can stop giving, so that will help some with overall cost. Gonzales AJ, Humphrey WR, Messamore JE, et al. APOQUEL FOR CATS - DOSAGE and SIDE EFFECTS - JNH PETS Pharmacokinetics of a single dose of oclacitinib maleate as a top dress Apoquel should be shipped with extreme caution when temperature is below 35 degrees Fahrenheit. Drake GJ, Nuttall T, Lpez J, et al. Pasture-Associated Respiratory Disease in Horses Acepromazine affects animals and humans by depressing the central nervous system. More studies are necessary to confirm oclacitinibs effects in non-allergic diseases and what other immune-mediated mechanisms may be involved. Thats def not nothing but its not insane. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. Because one of mine had similar food allergies and I was told the serum would not address that. Oclacitinib Maleate (Apoquel) - Veterinary Partner - VIN Ultimately, my vet did not recommend we go down that route. APOQUEL tablets may be administered with or without food. Rectal Prolapse in Dogs and Cats. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Let's look at the differences between these two medications, as well as some other treatment options for your dog's allergies. 9. 23. Dosage and administration For oral use. Vet Dermatol 2013;24(6):587-597, e141-142. Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. You are encouraged to speak with your prescriber as to the appropriate use of any medication. Option 1 is the cheap/easy route, but comes with risks. Oclacitinib was well tolerated in both studies. Apoquel | Zoetis Petcare Cyclosporine, which is approved for the treatment of canine atopic dermatitis, has an onset of efficacy of up to 4 weeks. 18. Vet Dermatol 2017;28(5):512-e123. Milder cases of asthma are still associated with coughing, airway inflammation, mucous production, and poor performance.. The dosage for dogs 15-19.9 lbs is one 3.6 mg tablet twice daily. Apoquel Prices, Coupons & Savings Tips - GoodRx We do a loading dose for 7 days, then every other day for 7 doses (so 14 days) then work to figure out how far apart we can go with our daily dose. 9. What company did you use? Because insects are omnipresent in the horses environment at least some portion of the year, IBH is particularly labor-intensive to manage. Apoquel is an anti-itch tablet given twice daily for the first . So new drugs such Atopica and Apoquel are prescribed routinely, to help dog owners find a quick fix for dog allergies. Cosgrove SB, Wren JA, Cleaver DM, et al. This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. We. to 14 days, and then administered once daily for maintenance therapy. It is an anti-inflammatory drug from the class of drugs known as Janus kinase (JAK) inhibitors. 27. Pruritus is a common clinical sign in allergic skin diseases. Apoquel Dosage for Dogs. There is a new drug available to help allergic horses: Apoquel. The second option is serum (blood) testing. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Vet Dermatol 2016;27(1):22-e7. Apoquel is a prescription medication used to treat itching and inflammation in dogs. She has been allergy tested! In more severe cases, Apoquel can be given twice per day. Yes, we looked into this approach, but unfortunately it was not a viable option for my horse for a variety of reasons including other health factors and severity of allergies. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. Researchers have proven flaxseed reduces skin lesions in IBH horses (ONeill et al., 2002). In cats, this medication can cause excitement rather than sedation. Haugh IM, Watson IT, Menter MA. I paid $250 for 100 pills (thats 20 5-pill doses). So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. Summer-pasture-associated horses tend to be triggered by spring/summer allergens like grasses and trees, and classic horses tend to be triggered by barn dust and mold spores. Weve been doing really well with every other day dosing. It is important to address that the use of oclacitinib in cats is off-label, and owners should be informed before using oclacitinib in this species. Your Price: $2.20. Apoquel is a prescription dog allergy medicine used for the control of itch associated with allergic dermatitis and control of atopic dermatitis in dogs 12 months and older. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Unless my vet (and an unaffiliated nutritionist) I consulted are wrong-- I was told that allergy serum is only possible/effective for some allergies and a lot of food-based ones are not on the list. Each dosage is sold per tablet, in 20 count, or 100 count bottles. Therefore, it is recommended that dogs 6.6-9.9 lbs take of a 3.6 mg tablet twice daily as an initial dosage. As a result, muscles relax and cause heavy sedation, notes DailyMed. And some can got a lower dose or a further spread out dose. The American company "Zoetis Inc" created the drug Apoquel, which deservedly occupies a leading position among drugs for eliminating itching in dogs, regardless of its etiology. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . 28. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis. Gonzales AJ, Humphrey WR, Messamore JE, et al. On the label for dogs, Apoquel is used every 12 hours for the first 14 days of use, then backed down to dosing every 24 hours once a day. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is flaxseed. Urticaria (hives) is the most widely reported presentation of a skin allergy. Apoquel For Dogs: Dosage Apoquel comes in three tablet sizes: 3.6mg, 5.4mg, and 16mg. Interleukin-31: its role in canine pruritus and naturally occurring canine atopic dermatitis. BMC Vet Res 2019;15(1):137. on various factors. At that point, the treatment can be changed to oclacitinib. Therefore, it is important to get your veterinarian involved right away. I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. Haugh IM, Watson IT, Menter MA. The drug is primarily used as a tranquilizer to calm anxious pets, especially dogs and horses, according to DailyMed. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. I know there are some cases where the horse only needs 5 pills 1x a weekothers where its every 4 days.My vet did say she has one client whos horse has gone down to 2 pills every 3 days. Apoquel for horses - Horse Care - Chronicle Forums In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). Once you have the horse's symptoms under control, you can try re-introducing hay. Serious side effects include seizures, abnormal breathing, incoordination, muscle tremors, and coma. Like other medications in its class, it may also be used off . Many of these cytokines bind to cytokine receptors that have JAK enzymes associated with their cytoplasmic portion. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered Rosenkrantz WS, Bourgeois AS. Insect and pollen season is here. Stay on top of the most recent Horse Health news with, If interested in adopting this horse, please submit an Adoption Inquiry via our website: Allaboutequine dot org. 25. Learn how allergies happen, how they affect your horses body, and how to avoid or treat them. Because many respiratory allergies come from the dust in hay and bedding, veterinarians generally recommend maximizing fresh-air time through turnout. Levy BJ, Linder KE, Olivry T. The role of oclacitinib in the management of ischaemic dermatopathy in four dogs. Barns can also have noxious gases from the ammonia in urine. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Apoquel for Dogs - Drugs.com Available As Tablets For use with Canine Strengths 3.6 mg 5.4 mg 16 mg Cosgrove SB, Cleaver DM, King VL, et al. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. Ortalda C, Noli C, Colombo S, et al. Download Apoquel Information Sheet. According to the manufacturer's dosage chart, a large breed weighing between 130 and 175lbs should take two Apoquel 16mg daily. Ortalda C, Noli C, Colombo S, et al. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Apoquel starts relieving allergic dog itch and inflammation due to skin allergies within 4 hours and controls it within 24 hours. Long term itch reduction. 14. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label.30. Pulsoni D, Freire A, Ferreira DR. Juvenile-onset ischemic dermatopathy. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as insect bite hypersensitivity (IBH). Everything on Apoquel: The Popular Allergy Medicine for Dogs Remove all nonessential supplements and topical solutions from your horses diet and routine. Noli C, Matricoti I, Schievano C. A double-blinded, randomized, methylprednisolone-controlled study on the efficacy of oclacitinib in the management of pruritus in cats with nonflea nonfood-induced hypersensitivity dermatitis. 1. Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. Panteri A, Strehlau G, Helbig R, et al. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea. Apoquel can only be obtained with a prescription; it is available as film-coated tablets and chewable tablets in different strengths to cover a range of dog weights. Vet Dermatol 2013;24(5):479-e114. @vxf111 we were told the same thing for food allergiesthat they did not make serums fot them because they were not very effecttive and the the expectation was that the allergen be removed from the diet. 2: The Barn and Pasture: Horses with Summer-Pasture-Associated disease usually have less symptoms when kept in the barn during the warmer months. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. Many allergic reactions are evident as a mild case of transient hives. 1,2 The #1 prescribed medicine for allergic itch in dogs. What Will Happen If a Human Takes Acepromazine? - Reference.com I spend $150 a month on my horse on apoquel. I was one of the veterinarians involved in early field trials for Apoquel in horses. Apoquel | European Medicines Agency Orthobiologic Options for Treating Horses. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. . Its important to know, however, that some horses can have BOTH types, and will need to managed year-round!What are your treatment and management options? Im currently struggling with my horses allergies. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. The Janus kinases (Jaks). Apoquel For Dogs: Safety, Dosage, Side Effects & More - Veterinary Place Immunotherapy, also called hyposensitization therapy, is a strategy used to gain allergen-specific immune tolerance, says Fultz. It can be given with or without food. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. Apoquel should not be used in breeding, pregnant, or lactating dogs. Dawn M. Cleaver, DVM Associate Director, Regulatory Affairs Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. Vet Dermatol 2015;26(1):23-30, e7-8. Since oclacitinib is a rather weak anti-inflammatory drug, it was suggested that remission of active moderate to severe atopic dermatitis be induced with a course of a broad inflammation-targeting drug, such as a short-acting glucocorticoid, until clinical signs become mild. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. Apoquel | Zoetis US 16. 1. Treatment will probably need to repeated somewhere between 1 and 6 weeks after the initial treatment course. 30. "Even though the drug is currently labeled for use in dogs (with. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. Yamaoka K, Saharinen P, Pesu M, et al. Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines.